WNT Stem Cell
Gene co-expression module in Colorectal carcinoma
| Category | GF response |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
LGR5 is the canonical WNT/R-spondin receptor and colon stem cell marker. AXIN2 is a direct transcriptional target of beta-catenin/WNT signaling and a negative feedback regulator. RNF43 is a WNT target gene that negatively regulates WNT signaling. SATB2 marks colon epithelial identity. CFTR and NOX1 are colon epithelial-specific. CDCA7 is a MYC target involved in cell proliferation downstream of WNT. SMARCC1 (SWI/SNF) and RBM39 participate in WNT-driven transcriptional programs. AKAP1 and PLCB4 regulate downstream signaling. This module strongly represents the WNT signaling / colon stem cell program in CRC, consistent with its neighbor M36 (AP-1/IEG), since WNT and AP-1 co-activate in LGR5+ stem/progenitor CRC cells.
Genes
Most correlated modules
- Ceramide Lipid Metabolism · correlation 0.87
- RNA Splicing · correlation 0.78
- ER Protein Processing · correlation 0.76
- Ribosome Biogenesis · correlation 0.70
- Pre-mRNA Splicing · correlation 0.63
- Golgi-Nuclear Organization · correlation 0.61
- Colonocyte Differentiation · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.