RNA Pol I/III Transcription
Gene co-expression module in Colorectal carcinoma
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
SAP18 is a Sin3A/HDAC co-repressor complex component. GTF3A encodes TFIIIA, a zinc-finger transcription factor required for RNA Polymerase III-dependent 5S rRNA transcription. POLR1D is a shared subunit of RNA Polymerase I and III. SNRPB2 (U2 snRNP B'' protein) participates in pre-mRNA splicing. POMP (proteasome maturation protein) and UCHL3 (deubiquitinase) contribute proteasome assembly. Together the module reflects a nuclear RNA Pol I/III transcription and chromatin regulation program with proteasome assembly. MRPL57 and SUGT1 are peripheral members from the mitochondrial/kinetochore neighborhood.
Genes
Most correlated modules
- Housekeeping Proteostasis · correlation 0.90
- Mitochondrial Import & Complex I · correlation 0.81
- ER Membrane Biogenesis · correlation 0.77
- Translation Initiation Factors · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.