Mitochondrial Import & Complex I
Gene co-expression module in Colorectal carcinoma
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
TOMM7 (TOM complex mitochondrial protein import), NDUFA4 and NDUFB2 (NADH dehydrogenase Complex I accessory subunits), CHCHD2 (mitochondrial intermembrane space protein linked to Complex IV assembly and PINK1/Parkin pathway), and FIS1 (mitochondrial fission protein) define a mitochondrial biogenesis and import program. SEM1, UBL5, and PFDN5 contribute protein quality control. Neighbor M32 is pure OxPhos Complex III/IV, supporting that this batch neighborhood centers on mitochondrial function.
Genes
Most correlated modules
- Translation Initiation Factors · correlation 0.93
- SUMOylation Pathway · correlation 0.90
- ER Protein Processing · correlation 0.87
- OxPhos Complex III/IV · correlation 0.86
- eIF3 Translation Initiation · correlation 0.84
- ER Signal Peptide Processing · correlation 0.82
- Actin-Vesicle Coupling · correlation 0.82
- Transcriptional Ubiquitin Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.