ER Membrane Biogenesis
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
BCAP31, PGRMC1, PRDX4, ALG3, SSR4 are all ER-resident membrane or luminal proteins involved in protein folding, lipid metabolism, and glycosylation. EIF2S3 and EIF1AX (translation initiation factors) and MCTS1/MALSU1 (ribosome-associated) reflect coupled ER biogenesis and translation. PDHA1 is peripheral. This module neighbors M15 (ER translocon/glycosylation), together forming an ER biogenesis neighborhood. Strong coherence supports a tight ER membrane/folding program.
Genes
Most correlated modules
- TRiC/CCT Core Complex · correlation 0.84
- ER Protein Processing · correlation 0.80
- Chromatin-coupled Splicing · correlation 0.80
- RNA-protein Transport · correlation 0.80
- Ubiquitin-Proteasome System · correlation 0.78
- RNA Pol I/III Transcription · correlation 0.77
- Actin-Vesicle Coupling · correlation 0.77
- Lysosomal Autophagy Membrane · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.