Housekeeping Proteostasis

Gene co-expression module in Colorectal carcinoma

Why this annotation

This module lacks a single dominant functional theme but contains several housekeeping genes active in protein modification, RNA processing, and metabolic maintenance. SPCS1 (signal peptidase complex subunit 1, ER translocation), CNBP (zinc finger RNA binding, translational regulation), THOC7 (THO complex, mRNA export), PCMT1 (protein-L-isoaspartate methyltransferase, protein repair), PDCD2 (programmed cell death, RNA binding), CSNK2B (casein kinase 2 beta, ubiquitous kinase), SDHC (succinate dehydrogenase complex subunit C, ETC complex II), GLRX3 (glutaredoxin 3, redox homeostasis), TMEM14B/C (mitochondrial inner membrane), CUTA (copper tolerance, metal homeostasis), EBPL (emopamil binding protein-like, sterol metabolism). Uniform expression across all subsets with strong coherence supports a housekeeping designation. The module is a mixed housekeeping program spanning ER processing, RNA export, redox balance, and mitochondrial function. Neighbor context: proximity to M9 (mitochondrial/ETC) and M72 (mitoribosome) suggests these uniformly expressed housekeeping modules cluster together in the network, consistent with constitutive metabolic maintenance programs.

Genes

Most correlated modules

• Mitochondrial OXPHOS · correlation 0.94
• Nuclear Assembly · correlation 0.90
• RNA Pol I/III Transcription · correlation 0.90
• SUMOylation Pathway · correlation 0.89
• TRiC/CCT Core Complex · correlation 0.88
• Proteasome Degradation · correlation 0.87
• Housekeeping Mixed · correlation 0.86
• TRiC Chaperonin Complex · correlation 0.86

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.