cDC1 NFAT Signaling
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Enriched in cDC1 (9x). Hub genes include NFATC3 (NFAT transcription factor, immune activation and DC maturation), MAPK1 (ERK2, central signaling kinase), VAV3 (Rho GEF, cDC1-enriched, regulates actin and immune signaling), ESRRA (nuclear receptor regulating mitochondrial biogenesis and DC metabolism), GIGYF2 (translational repressor linked to immune regulation), SOGA1 (autophagy/mTOR regulation), and ARHGAP17 (Rho GAP). NFATC3 and MAPK1 are canonical immune signaling components. The cDC1 enrichment with NFATC3/MAPK1/VAV3 suggests a cDC1-specific transcriptional activation/signaling program. Moderate coherence. Neighbor M6 (prolif_DC) shares SNAPC1 overlap, but the dominant cDC1 signal and NFATC3 hub distinguish this as a cDC1 activation program.
Genes
Most correlated modules
- DNA Damage Repair · correlation 0.83
- DC Proliferation Program · correlation 0.82
- Phagocytic Cytoskeletal · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.