Phagocytic Cytoskeletal
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 13 genes have a known function matching the annotation |
Why this annotation
This is a weak coherence module with low mean expression and no dominant subset enrichment. Hub genes: ZNF609 (zinc finger transcription factor), GTF2I (general transcription factor IIi, Williams syndrome gene), ELMO1 (engulfment and cell motility, phagocytosis/Rac1 activation), GNL3 (nucleostemin, nucleolar GTPase), KDM5A (histone H3K4 demethylase), ZBTB11 (zinc finger transcription factor), TNRC6B (GW182, miRNA silencing), MFAP1 (spliceosome), LNPEP (leucyl/cystinyl aminopeptidase), RRM2B (ribonucleotide reductase, DNA repair/p53 target), DIAPH2 (diaphanous formin, actin cytoskeleton), SUPT6H (transcription elongation), TNKS2 (tankyrase, Wnt/telomere). The module is weakly coherent and functionally heterogeneous. ELMO1 and DIAPH2 suggest cytoskeletal/phagocytic activity. GTF2I and SUPT6H suggest transcription. The strongest biological signal given ELMO1 (known role in phagocytosis and DC migration) and DIAPH2 (actin polymerization) is cytoskeletal/engulfment, but the module is too mixed for high certainty. Treatment response is notably negative (delta_treatment = -0.165), suggesting disease-associated activity.
Genes
Most correlated modules
- Proliferating DC Program · correlation 0.90
- Transcriptional Homeostasis · correlation 0.87
- RNA Processing Proliferation · correlation 0.86
- Genome Maintenance · correlation 0.86
- p53 Transcriptional Regulation · correlation 0.85
- Golgi-Endosomal Trafficking · correlation 0.82
- cDC1 NFAT Signaling · correlation 0.80
- cDC1 Epigenetic Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.