DC Proliferation Program
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
This module is enriched in mDC and prolif_DC subsets. CHD9 (chromatin remodeler, top hub) is involved in transcriptional regulation. GAS2L3, TTF1, GPATCH11, TUT4, and MPRIP are enriched in prolif_DC, suggesting a proliferation-associated program. GAS2L3 is a cytokinesis regulator. TTF1 (transcription termination factor) and GPATCH11 (RNA processing) are linked to cell cycle. PTPN22 is a phosphatase regulating immune signaling. MAVS is an antiviral innate immune adaptor. IL16 is a cytokine. MBD4 is a DNA repair enzyme. PABPN1 is involved in RNA processing. The module is moderate coherence and mixes chromatin remodeling, RNA processing, and proliferation-associated genes. The prolif_DC enrichment of multiple genes and the mDC enrichment overall suggest this represents a DC proliferation/chromatin remodeling program rather than a pure inflammatory one. EVL (actin dynamics) and MPRIP (myosin phosphatase) add cytoskeletal elements consistent with dividing cells.
Genes
Most correlated modules
- cDC1 Epigenetic Regulation · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.89
- Gut-Homing DC · correlation 0.89
- Endosomal DC Program · correlation 0.88
- Telomere Maintenance · correlation 0.86
- RNA Processing Proliferation · correlation 0.85
- Lysosomal Vesicular Trafficking · correlation 0.84
- cDC1 NFAT Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.