DNA Damage Repair
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
XPA is the top-ranked functional anchor — it encodes xeroderma pigmentosum complementation group A protein, a critical scaffold for nucleotide excision repair (NER). CTDSP1 (RNA Pol II CTD phosphatase) participates in transcription-coupled NER. AHCYL1 (S-adenosylhomocysteine hydrolase-like) is involved in the methionine cycle linked to DNA methylation/repair. ADAM15 and SLC39A3 are less clearly linked. Module coherence is moderate and expression is low/uniform. The treatment-positive delta (increases post-treatment in CD) may reflect restoration of DNA repair capacity. Given the moderate coherence and mixed membership, certainty is limited.
Genes
Most correlated modules
- Gut-Homing DC · correlation 0.89
- DNA Damage Response · correlation 0.83
- cDC1 NFAT Signaling · correlation 0.83
- DC Proliferation Program · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.