SNARE Vesicular Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include multiple SNARE/vesicle fusion proteins (STXBP2, SNAP23, VAPA, CHMP4A) alongside lysosomal components (CTSA, LAMTOR5, ATP6AP2) and mitochondrial factors (MTIF3, FIS1, MPC1). The dominant program is vesicular trafficking and membrane fusion, with STXBP2 (syntaxin-binding/exocytosis), SNAP23 (SNARE docking), VAPA (ER-Golgi contact sites), and CHMP4A (ESCRT-III endosomal sorting) as core drivers. Lysosomal genes (CTSA, ATP6AP2) are co-expressed, consistent with the endolysosomal trafficking axis. Moderate coherence reflects the mixed vesicular/lysosomal/mitochondrial composition. Neighbor M139 shares ER trafficking (SFT2D2, VCPIP1), reinforcing an intracellular membrane trafficking neighborhood.
Genes
Most correlated modules
- Proliferating DC Housekeeping · correlation 0.80
- ER Protein Folding · correlation 0.80
- Type I Interferon · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.