ER Protein Folding
Gene co-expression module in Dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes CALR, PDIA3, PDIA6, CANX, P4HB, PPIB, HSP90B1 are all canonical ER chaperones involved in protein folding and quality control. TMED2 and TRAM1 are ER/COPI trafficking components. MANF and SDF2L1 are ER stress-protective/responsive factors. This module represents the core ER protein folding and quality control machinery. Uniform expression across DC subsets and moderate coherence indicate a broadly active housekeeping ER program. In the context of neighboring modules (M103 with UPR sensors, M29 with endosomal trafficking), this module anchors the ER chaperone arm of the antigen processing axis.
Genes
Most correlated modules
- Type I Interferon · correlation 0.89
- ER Translocon Processing · correlation 0.84
- Proliferating DC Mixed · correlation 0.84
- Endosomal Trafficking · correlation 0.83
- Unfolded Protein Response · correlation 0.81
- Proliferating DC Housekeeping · correlation 0.80
- SNARE Vesicular Trafficking · correlation 0.80
- ER Protein Processing · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.