Proliferating DC Housekeeping
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Strongly enriched in prolif_DC (35.8x) with weak coherence. Hub genes include CLTC (clathrin heavy chain, endocytosis), TOMM20 (mitochondrial outer membrane import receptor), GNB1 (G-protein beta-1 subunit), DDX24 (RNA helicase), REEP3 (ER membrane shaping), APH1A (gamma-secretase component), EIF4G2 (translation initiation), CAPZB (actin filament capping), ARF3 (ARF GTPase, vesicle budding), and BCAP31 (ER membrane chaperone). The prolif_DC enrichment and weak coherence suggest this is a mixed housekeeping module expressed in proliferating DCs, combining general cellular machinery (translation, ER, mitochondria, endocytosis) rather than a specific biological program. The weak coherence and broad functional diversity of genes support a housekeeping interpretation in a proliferating DC context.
Genes
Most correlated modules
- Cell Cycle Checkpoint · correlation 0.86
- DC Actin Migration · correlation 0.84
- ER Protein Folding · correlation 0.80
- SNARE Vesicular Trafficking · correlation 0.80
- ER Protein Processing · correlation 0.80
- ER Membrane Biogenesis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.