Acute NF-κB Response
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 18 genes have a known function matching the annotation |
Why this annotation
This core-coherence module is dominated by canonical NF-κB pathway genes and immediate-early response transcription factors: TNFAIP3 (A20, NF-κB negative feedback), NFKBIA, NFKBIZ, NFKBID (IκB family members), IER3 (immediate early response), MAFF, KLF6, BHLHE40, ZFP36L1 (stress-responsive TFs), SOCS3 (JAK-STAT feedback), GADD45B (stress/DNA damage response), CD83 (DC maturation marker), ICAM1 (adhesion, NF-κB target), and RGS1 (regulator of G-protein signaling). The pattern of IκB proteins plus A20 plus immediate-early genes is the hallmark of acute NF-κB activation with negative feedback — a DC maturation/inflammatory stimulus response. This differs from M117 which captures the sustained NF-κB survival program; M140 represents the acute transcriptional response to inflammatory stimuli.
Genes
Most correlated modules
- NF-κB DC Activation · correlation 0.87
- mDC Tolerogenic Identity · correlation 0.82
- Lysosomal Antigen Processing · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.