mDC Tolerogenic Identity
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
SPIB (ETS transcription factor, master regulator of mDC/pDC identity, mDC 3.6x) is the clearest identity anchor. IDO2 (indoleamine 2,3-dioxygenase 2, tryptophan catabolism, immune tolerance, mDC 2.4x) and NFIL3 (bZIP TF required for DC development) reinforce mDC identity with tolerogenic function. RHBDF2 (iRhom2, regulates ADAM17/TACE for TNF and EGFR ligand shedding, mDC 3.2x) and TAB2 (TAK1 adaptor, NF-κB/MAPK) add inflammatory cytokine processing. C2CD2L and MCOLN2 (mucolipin-2, lysosomal Ca2+ channel) are mDC-enriched. ETV6 (ETS TF, hematopoietic development) and NFAT5 (osmotic/inflammatory TF) support DC identity. Strong coherence and consistent mDC enrichment confirm this as an mDC identity module with tolerogenic features.
Genes
Most correlated modules
- TNF/NF-κB DC Activation · correlation 0.90
- NF-κB DC Activation · correlation 0.90
- Regulatory mDC Activation · correlation 0.84
- Acute NF-κB Response · correlation 0.82
- Tolerogenic mDC Activation · correlation 0.81
- Lysosomal Antigen Processing · correlation 0.80
- CD1 Lipid Presentation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.