NF-κB DC Activation
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes GPR183, REL, NFKB1, BCL3, BCL2A1, G0S2, ETV3, CMTM6, and CXCR4 form a coherent NF-κB survival/activation signature in mDCs. GPR183 (EBI2) is a chemokine receptor guiding DC migration; REL and NFKB1 are canonical NF-κB subunits; BCL3 is an IκB-family NF-κB modulator; BCL2A1 is an NF-κB target anti-apoptotic gene; G0S2 is an NF-κB-regulated survival gene; CMTM6 stabilizes PD-L1 and is expressed on activated DCs; NINJ1 mediates cell adhesion; SQSTM1 (p62) links NF-κB to autophagy. The module is tightly co-regulated (core coherence) and strongly enriched in mDCs. This represents a canonical NF-κB-driven DC survival and activation state, distinct from the acute inflammatory response captured in M140.
Genes
Most correlated modules
- mDC Tolerogenic Identity · correlation 0.90
- Acute NF-κB Response · correlation 0.87
- Lysosomal Antigen Processing · correlation 0.84
- Regulatory mDC Activation · correlation 0.83
- NRF2 Metabolic Stress · correlation 0.77
- CD1 Lipid Presentation · correlation 0.77
- IFNγ-primed Phagocytosis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.