Lysosomal Antigen Processing
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Key hub genes include LAMP2 (lysosomal membrane glycoprotein), SLC15A3 (lysosomal peptide transporter critical for antigen processing), CTSC (cathepsin C, lysosomal cysteine protease), ATP6V1G1 (vacuolar ATPase subunit for lysosomal acidification), ARL8B (lysosome positioning GTPase), CD86 (costimulatory molecule upregulated after antigen encounter), TYROBP (DAP12, signaling adaptor for myeloid activation), SIRPA (inhibitory receptor on mDCs), ZEB2 (mDC identity transcription factor), MALT1 (paracaspase in NF-κB/BCR signaling), and ARRB2 (beta-arrestin 2, regulates receptor internalization and endosomal trafficking). The module is enriched in mDCs and combines lysosomal antigen processing machinery with DC activation markers. Neighbor M117 captures NF-κB survival signaling, while M87 captures the downstream antigen processing and phagocytic machinery, consistent with co-expression in activated mDCs.
Genes
Most correlated modules
- NF-κB DC Activation · correlation 0.84
- Regulatory mDC Activation · correlation 0.81
- mDC Tolerogenic Identity · correlation 0.80
- Tolerogenic mDC Activation · correlation 0.78
- IFNγ-primed Phagocytosis · correlation 0.78
- CD1 Lipid Presentation · correlation 0.76
- mRNA Processing & Translation · correlation 0.72
- Acute NF-κB Response · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.