TGF-beta Response
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include TGFBR1 and TGFBR2 (TGF-beta receptors I and II), TGIF1 (TGF-beta-induced factor homeobox, a SMAD2/3 co-repressor), NR3C1 (glucocorticoid receptor), KLF9 (glucocorticoid-responsive KLF transcription factor), IRAK3 (IRAK-M, negative regulator of TLR/IL-1 signaling promoting tolerance), TET3 (epigenetic DNA demethylation), IRS2 (PI3K/Akt signaling). The module increases post-treatment and with UC remission, consistent with an anti-inflammatory/tolerogenic TGF-beta and glucocorticoid response program. IRAK3 is a well-established tolerance mediator in DCs.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.74
- NRF2 Metabolic Stress · correlation 0.74
- MMP9 Effector cDC2 · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.