Chromatin Remodeling
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include ANKRD12, BRD4, ANKRD44, SPEN, MED13, ARID4B, SMARCA2, KDM2A, PHF3, AGO2 — a collection of chromatin remodelers (SMARCA2, ARID4B, KDM2A, BRD4), transcriptional co-regulators (SPEN, MED13, PHF3), and post-transcriptional regulators (AGO2). SPEN is a transcriptional repressor; BRD4 is a bromodomain protein involved in transcriptional elongation; SMARCA2 is a SWI/SNF chromatin remodeler; KDM2A is a histone demethylase. This module represents a broad chromatin remodeling and transcriptional regulation program. Coherence is moderate, with several weak members, suggesting a mixed but related epigenetic regulatory program. INPP5D (SHIP1) is a phosphatase relevant to DC signaling. The module is uniformly expressed with no inflammation association.
Genes
Most correlated modules
- Alternative Splicing · correlation 0.85
- Transcriptional Homeostasis · correlation 0.85
- RNA Splicing Processing · correlation 0.84
- mDC Vesicular Trafficking · correlation 0.79
- Actomyosin Cytoskeletal · correlation 0.78
- mRNA Processing & Translation · correlation 0.77
- Golgi-Lysosome Trafficking · correlation 0.75
- Endosomal DC Trafficking · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.