NRF2 Metabolic Stress
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes include NAMPT (NAD+ biosynthesis, key metabolic enzyme), PFKFB3 (glycolysis regulator), NFE2L2 (NRF2, master oxidative stress TF), NR4A3 (nuclear receptor activated by metabolic stress), SGK1 (serum/glucocorticoid kinase), VEGFA (hypoxia-induced angiogenic factor), PTGER4 (prostaglandin E2 receptor), PDE4B (cAMP phosphodiesterase), and INSIG1 (sterol sensing). This is a coherent NRF2/metabolic reprogramming and hypoxia-stress response module, broadly expressed across DC subsets. Neighbor context with M141 (AP-1 activation) and M170 (OLR1+ cDC2) supports an inflammatory metabolic adaptation program.
Genes
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.89
- DC Proliferation Program · correlation 0.84
- DC Metabolic Activation · correlation 0.82
- OLR1+ cDC2 Subset · correlation 0.82
- MMP9 Effector cDC2 · correlation 0.78
- NF-κB DC Activation · correlation 0.77
- TGF-beta Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.