MMP9 Effector cDC2
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include ANKH (inorganic pyrophosphate transporter), SDS (serine dehydratase, amino acid catabolism), PHLDB1 (pleckstrin homology domain, PI3K signaling), SERINC5 (serine incorporator, membrane lipid), MMP9 (matrix metalloproteinase-9, ECM remodeling and inflammation), TNFSF14 (LIGHT, TNF superfamily member that activates T cells and promotes inflammation), MEF2D (transcription factor), PAPSS2 (PAPS synthase, sulfation of proteoglycans/steroids). MMP9 and TNFSF14 are the clearest inflammatory effectors. The module is negatively associated with inflammation (delta_inflammation = -0.328) but positively with treatment response, suggesting it may mark a homeostatic cDC2 state that is suppressed during active inflammation. MMP9+TNFSF14 co-expression in cDC2s points to an effector DC program involved in tissue remodeling.
Genes
Most correlated modules
- OLR1+ cDC2 Subset · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.89
- Tolerogenic Lipid Metabolism · correlation 0.88
- AP-1 cDC2 Activation · correlation 0.88
- DC Metabolic Activation · correlation 0.85
- NRF2 Metabolic Stress · correlation 0.78
- TGF-beta Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.