Lysosomal AP-3 Trafficking
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include AP3B1 (AP-3 adaptor complex beta subunit, essential for lysosomal biogenesis and MHC-II trafficking in DCs), SNAP29 (SNARE protein mediating autophagosome-lysosome and late endosome fusion), DPP7 (dipeptidyl peptidase 7, lysosomal serine protease), STK38 (NDR1 kinase, regulates autophagy and vesicle trafficking), GALNT1 (O-glycosyltransferase, Golgi), and PHACTR2 (phosphatase/actin regulator). AP3B1 is a well-established regulator of lysosomal trafficking and antigen processing in DCs. SNAP29 and STK38 link to autophagy/lysosomal fusion. DPP7 is a lysosomal protease. This module represents lysosomal vesicle trafficking and antigen processing machinery. Neighbor M54 also has vesicular trafficking genes, supporting this neighborhood's focus on membrane trafficking.
Genes
Most correlated modules
- Leukotriene IL-18 Signaling · correlation 0.87
- mDC Vesicular Trafficking · correlation 0.84
- Endosomal Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.