Leukotriene IL-18 Signaling
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
CYSLTR1 (cysteinyl leukotriene receptor 1, mediates pro-inflammatory leukotriene signaling, enriched in cDC2/prolif_DC) and IL18 (pro-inflammatory cytokine promoting IFN-gamma, enriched in cDC2) are the top hub genes. IKBKB (IKK-beta, canonical NF-κB activator), MAP3K20 (ZAK, stress-activated MAPK upstream of JNK/p38), and PSTPIP2 (regulates NLRP3 inflammasome and inflammatory signaling) reinforce an innate inflammatory signaling program. SPTLC2 (sphingolipid synthesis, bioactive lipid mediators) and TPP2 (antigen processing peptidase) add lipid mediator and antigen processing context. This module represents leukotriene/IL-18-driven inflammatory signaling in cDC2s.
Genes
Most correlated modules
- Lysosomal AP-3 Trafficking · correlation 0.87
- Endosomal Trafficking · correlation 0.84
- cDC2 CLR Signaling · correlation 0.83
- mDC Vesicular Trafficking · correlation 0.81
- cDC2 Identity · correlation 0.81
- DC Actin Migration · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.