Endosomal Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include SORL1 (endosomal sorting receptor), BORCS7 (BLOC-1-related complex subunit, lysosome positioning), RCSD1 (actin dynamics/CapZIP), SSH2 (slingshot phosphatase, actin remodeling), ARHGAP21 (Rho GTPase-activating protein), INPP4A (phosphoinositide phosphatase regulating endosomal trafficking), MAPK14 (p38 MAPK), TRAF3IP3 (endosomal/immune signaling). The combination of endosomal sorting, lysosome positioning, and actin/cytoskeletal regulators points to vesicular trafficking and endosomal regulation. Moderate coherence reflects a mixed but related program. Neighbor M77 (cDC2 identity) supports this as a cDC2-associated trafficking program.
Genes
Most correlated modules
- cDC2 Identity · correlation 0.92
- cDC2 Identity · correlation 0.87
- Leukotriene IL-18 Signaling · correlation 0.84
- cDC2 Identity · correlation 0.83
- cDC2 Identity · correlation 0.83
- mDC Vesicular Trafficking · correlation 0.81
- Lysosomal AP-3 Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.