mDC Vesicular Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Strongly enriched in mDC (14.4x). Hub genes include TSPAN14 (tetraspanin that regulates ADAM10 trafficking and DC surface presentation), ACAP2 (ARF1 GAP involved in endosomal/vesicular trafficking), VTI1B (v-SNARE mediating endosomal fusion), DOCK11 (Rho GEF), LARP1 (RNA-binding protein regulated by mTOR), ARID1A (chromatin remodeling), CDK12 (transcription-coupled kinase), and SF3A1 (splicing factor). The mDC enrichment combined with vesicular trafficking genes (TSPAN14, ACAP2, VTI1B) and RNA regulatory genes suggests an mDC-specific program linking post-transcriptional regulation with endosomal/vesicular trafficking. Moderate coherence with many weak members reflects a mixed but mDC-biased program.
Genes
Most correlated modules
- Lysosomal AP-3 Trafficking · correlation 0.84
- DC Actin Migration · correlation 0.81
- Endosomal Trafficking · correlation 0.81
- Leukotriene IL-18 Signaling · correlation 0.81
- Genome Maintenance · correlation 0.80
- Chromatin Remodeling · correlation 0.79
- Golgi-Lysosome Trafficking · correlation 0.79
- Cell Cycle Checkpoint · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.