Integrin Adhesion Signaling
Gene co-expression module in Dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
ITGB1 (integrin beta-1) is the top hub gene by PageRank and is a canonical mediator of cell-ECM adhesion and migration. GNAS encodes a G-protein alpha subunit that modulates cAMP-dependent integrin activation and cell motility. TBC1D5 is a RAB7-GAP involved in endosomal recycling, including integrin trafficking back to the cell surface. The remaining genes (AIG1, HSD17B12, MAN1A1, CCNB1IP1) represent peripheral or loosely associated members spanning lipid metabolism and glycan processing, consistent with the moderate coherence rating. The module likely reflects a basal integrin-adhesion and membrane trafficking program in gut DCs, with no strong inflammatory or disease-state signal.
Genes
Most correlated modules
- DC Actin Migration · correlation 0.88
- cDC1 Epigenetic Regulation · correlation 0.79
- Cell Cycle Checkpoint · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.