cDC1 Epigenetic Regulation
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 38 genes have a known function matching the annotation |
Why this annotation
This module is enriched in cDC1 cells and contains HDAC9 (class IIa histone deacetylase, transcriptional repression), CCSER1 (chromatin/cell cycle), SCML1 (Polycomb group, epigenetic silencing), TRIM38 (E3 ubiquitin ligase, innate immune regulation), TLR10 (toll-like receptor, innate sensing), RNF138 (E3 ubiquitin ligase, DNA repair/immune), HTT (huntingtin, vesicle trafficking/autophagy), HPS5 (Hermansky-Pudlak syndrome, lysosomal biogenesis), NBEAL2 (BEACH domain, granule biogenesis), DST (dystonin, cytoskeletal), POM121 (nuclear pore), CSNK1G2 (casein kinase). The cDC1 enrichment and presence of HDAC9, SCML1, and TLR10 suggest a cDC1-specific epigenetic/transcriptional regulatory program. HDAC9 is known to regulate DC differentiation and tolerogenic programs. The module is moderate coherence with mixed functions but the cDC1 bias and epigenetic regulators are the dominant signal.
Genes
Most correlated modules
- DC Proliferation Program · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.85
- Lysosomal Vesicle Trafficking · correlation 0.83
- Proliferating DC Program · correlation 0.82
- RNA Processing Proliferation · correlation 0.81
- Endosomal DC Program · correlation 0.80
- Phagocytic Cytoskeletal · correlation 0.80
- Integrin Adhesion Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.