Cell Cycle Checkpoint
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include IMMT (inner mitochondrial membrane protein mitofilin), BNIP2 (BCL2-interacting mitochondrial protein), ROCK1 (Rho-associated kinase, cytoskeletal tension), WAPL (cohesin release factor, chromosome segregation), MAD1L1 (mitotic spindle assembly checkpoint), CSNK1A1 (casein kinase 1α, Wnt/cell cycle), and ATP6V0D1 (V-ATPase subunit). The module is moderate coherence and combines mitochondrial membrane integrity genes with cell cycle checkpoint components. WAPL and MAD1L1 are canonical cell cycle genes. The co-expression of mitochondrial and cell cycle genes is consistent with a proliferating/cycling DC state. Neighbor M6 is explicitly prolif_DC enriched, supporting a proliferation-linked interpretation.
Genes
Most correlated modules
- DC Actin Migration · correlation 0.92
- Golgi-Endosomal Trafficking · correlation 0.86
- Proliferating DC Housekeeping · correlation 0.86
- mDC Vesicular Trafficking · correlation 0.79
- Integrin Adhesion Signaling · correlation 0.79
- ER Protein Processing · correlation 0.78
- Unfolded Protein Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.