DC Actin Migration
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes DOCK2 (Rho GEF driving actin remodeling and DC migration), DIAPH1 (formin, actin polymerization), ERBIN (scaffolding/signaling), KTN1 (kinesin receptor for vesicle transport on actin/microtubules), CERK (ceramide kinase, lipid-actin coupling), and PRKAR1A (PKA signaling) collectively point to actin cytoskeletal organization and cell motility. DOCK2 is a canonical regulator of DC migration. CMIP modulates actin via Rho. Moderate coherence with uniform expression across DC subsets. Treatment decreases this module, consistent with reduced migratory activity post-therapy.
Genes
Most correlated modules
- Cell Cycle Checkpoint · correlation 0.92
- Lysosomal Vesicular Trafficking · correlation 0.89
- Integrin Adhesion Signaling · correlation 0.88
- Tolerogenic DC State · correlation 0.84
- Proliferating DC Housekeeping · correlation 0.84
- Endosomal Retromer Trafficking · correlation 0.84
- Golgi-Endosomal Trafficking · correlation 0.83
- mDC Vesicular Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.