Proliferating DC State
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
This weak-coherence module has all genes with weak membership, indicating poor co-regulation. Hub genes include NUMA1 (nuclear mitotic apparatus protein, mitotic spindle), DDX46 (DEAD-box RNA helicase, spliceosome/pre-mRNA processing), CHD4 (chromodomain helicase, NuRD complex), SF3B3 (splicing factor 3B subunit), WBP11 (splicing factor), UBTF (RNA Pol I transcription factor, ribosome biogenesis), MRPS11 (mitochondrial ribosomal protein), VPS41 (HOPS complex, lysosomal fusion), UBE2E1 (ubiquitin-conjugating enzyme). The weak coherence and all-weak membership suggest this is a poorly defined mixed module. NUMA1 enrichment in prolif_DC and its role in mitosis, combined with SF3B3 and WBP11 (splicing), DDX46 (RNA processing), and UBTF (rRNA transcription) suggest this may capture a proliferating DC state with mixed RNA processing/housekeeping genes. The weak coherence makes confident assignment difficult. The neighbor context (M162 is cDC1 identity, M160 is lysosomal) does not strongly constrain this module. Given NUMA1's role in mitosis and prolif_DC enrichment, a proliferation-related label is most supported, though the module is poorly defined.
Genes
Most correlated modules
- ER Membrane Biogenesis · correlation 0.80
- Sterol Biosynthesis cDC1 · correlation 0.77
- Actomyosin Cytoskeletal · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.