Actomyosin Cytoskeletal
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
PPP1R12A (myosin phosphatase targeting subunit, regulates actomyosin contractility), HOOK3 (dynein adaptor linking cytoskeleton to organelles), CNN2 (calponin-2, actin-binding), and ARHGAP5 (Rho GTPase-activating protein) form a cytoskeletal regulation core. PBRM1 (SWI/SNF subunit) and UBE3A (E3 ligase) add chromatin/proteostasis context. SRSF4, KHSRP, ATXN2L, G3BP1 represent RNA processing/stress granule components. HCK is a Src-family kinase active in myeloid cell migration. The module increases with inflammation and decreases with treatment, consistent with cytoskeletal remodeling during DC activation and migration.
Genes
Most correlated modules
- ER Membrane Biogenesis · correlation 0.80
- Chromatin Remodeling · correlation 0.78
- Endosomal DC Trafficking · correlation 0.76
- Golgi-Lysosome Trafficking · correlation 0.75
- Proliferating DC State · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.