Sterol Biosynthesis cDC1
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub gene FDFT1 (farnesyl-diphosphate farnesyltransferase 1) is the first committed enzyme in cholesterol/sterol biosynthesis. TMEM97 (also known as MAC30) is a progesterone receptor membrane component involved in cholesterol transport and is enriched in prolif_DC. PITHD1 is a mitochondrial/metabolic gene. S100B is a calcium-binding protein enriched in cDC1. POLD3 (DNA polymerase delta subunit, prolif_DC enriched) and CEP57 (centrosomal, prolif_DC enriched) suggest some proliferation-associated genes are co-expressed. SRSF11 and HNRNPDL are splicing factors (linking to the splicing neighborhood). The module is strongly enriched in cDC1 (10x) and shows moderate coherence. The dominant biological signal appears to be cholesterol/sterol metabolism (FDFT1, TMEM97) in cDC1s, with some admixture of proliferation-associated and splicing genes. FDFT1 and TMEM97 together point to a sterol biosynthesis/lipid metabolism program characteristic of cDC1s. The cDC1 enrichment and FDFT1 as top hub gene anchor this label.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.88
- Replication Licensing · correlation 0.82
- Proliferating DC State · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.