ER Membrane Biogenesis
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes by PageRank are predominantly ER-related: TOR2A (ER membrane torsin), SEC63 (ER translocon), KDSR (ER sphingolipid synthesis), RTN3 (ER shaping reticulon), and TSPAN3 (tetraspanin membrane protein). A secondary sub-program involves DNA replication factors (RPA1, RFC1, CHAF1A) enriched in prolif_DC, consistent with the moderate coherence score indicating a mixed module. The dominant program reflects ER membrane organization and protein translocation, expressed in cDC1 and mDC subsets. BET1 (ER-Golgi SNARE) and UBAP2 further support membrane trafficking context. The module does not cleanly fit antigen cross-presentation despite cDC1 enrichment, as the genes reflect general ER biogenesis rather than MHC-I loading machinery.
Genes
Most correlated modules
- RNA Processing Proliferation · correlation 0.84
- Golgi-Lysosome Trafficking · correlation 0.82
- Actomyosin Cytoskeletal · correlation 0.80
- Proliferating DC State · correlation 0.80
- Proliferating DC Housekeeping · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.