Metabolic Housekeeping
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes HADH (fatty acid oxidation), SAE1 (SUMO-activating enzyme), ACOT7 (acyl-CoA thioesterase), SUCLG1 (TCA cycle succinyl-CoA ligase), SLC25A39 (mitochondrial carrier), and UBE2T (ubiquitin-conjugating enzyme, DNA repair) point to a mixed metabolic/cell-cycle support program. Many genes are enriched in prolif_DC, and UBE2T is a known S-phase/DNA repair gene. RAD21 (cohesin), DDX39A (RNA helicase/splicing), IPO5 (importin), BRD7 (chromatin remodeling), and GPAA1 (GPI anchor biosynthesis) add to a broad housekeeping/metabolic support signature in proliferating DCs. The module is a neighbor of the clear proliferation modules (M97, M50, M104, M91), consistent with metabolic support of cell division. HADH and SUCLG1 anchor a mitochondrial/fatty acid oxidation component, while SAE1, UBE2T, RAD21 link to DNA replication support. The module likely captures metabolic and biosynthetic housekeeping programs co-activated in proliferating DCs rather than a pure cell-cycle module.
Genes
Most correlated modules
- MYC-driven Proliferation · correlation 0.93
- Endocytic Vesicular Trafficking · correlation 0.93
- DNA Replication Chromatin · correlation 0.93
- S-phase Replication · correlation 0.91
- Replication Licensing · correlation 0.90
- DC Proliferation · correlation 0.89
- Sterol Biosynthesis cDC1 · correlation 0.88
- RNA Splicing Processing · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.