Replication Licensing
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by MCM complex members (MCM3, MCM5, MCM6, MCM7 — replicative helicase subunits), HELLS (helicase, lymphoid-specific, DNA replication/chromatin), GMNN (geminin, replication licensing inhibitor expressed in S/G2), NASP (histone chaperone, replication-coupled), ATAD2 (chromatin remodeling, S-phase), RRM1 (ribonucleotide reductase, dNTP synthesis), RPA2 (replication protein A subunit), DNAJC9 (histone chaperone during replication), RBBP7 (chromatin assembly), RFC2 (replication factor C), NSD2 (histone methyltransferase). This module captures DNA replication licensing and chromatin assembly during S-phase, complementary to M97 (which captures dNTP synthesis and replication fork machinery). Both are S-phase but M91 emphasizes the MCM/licensing arm.
Genes
Most correlated modules
- S-phase Replication · correlation 0.98
- Metabolic Housekeeping · correlation 0.90
- Sterol Biosynthesis cDC1 · correlation 0.82
- Mitotic Spindle · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.