S-phase Replication
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are canonical S-phase and DNA replication markers: TK1 (thymidine kinase, S-phase), TYMS (thymidylate synthase, dNTP synthesis), DHFR (dihydrofolate reductase, nucleotide synthesis), PCNA (replication clamp), PCLAF (PCNA-associated, S-phase), FEN1 (Okazaki fragment processing), MCM4 (replicative helicase), RPA3 (replication protein A), RAD51AP1 (homologous recombination), DTYMK (dTMP kinase), DUT (dUTPase), NCAPD3 (condensin II, DNA organization), BRCA2 (HR repair), RANBP1 (Ran GTPase, nuclear transport during replication). Nearly all genes are massively enriched in prolif_DC. This is a tight S-phase DNA replication module. Neighbor context (M50, M104, M91) confirms a cluster of proliferation-related modules.
Genes
Most correlated modules
- Replication Licensing · correlation 0.98
- Metabolic Housekeeping · correlation 0.91
- Mitotic Proliferation · correlation 0.90
- Nucleotide Biosynthesis · correlation 0.89
- Mitotic Spindle · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.