JAK-STAT Cytokine Signaling
Gene co-expression module in Dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: STAT3 (pleiotropic cytokine signaling, IL-6/IL-10/IL-22 axis), ADAR (adenosine deaminase acting on RNA, dsRNA editing — also ISG), PTPN2 (tyrosine phosphatase that negatively regulates JAK-STAT signaling), ARID5A (RNA-binding protein that stabilizes STAT3 mRNA and IL-6 mRNA), ADPRH (ADP-ribosylhydrolase), SLC31A2 (copper transporter). STAT3 and ARID5A together strongly suggest IL-6/IL-10 family cytokine signaling. PTPN2 is a negative regulator of STAT1/STAT3. ADAR connects to RNA editing in the context of innate immune sensing. The module is uniformly expressed, has moderate coherence, and shows a trend toward inflammation without significance. The STAT3/ARID5A/PTPN2 axis points to cytokine-driven JAK-STAT regulation, likely IL-6 or IL-10 signaling in DCs. Neighbor modules M1 and M101 are IFN modules, and ADAR/PTPN2 are known IFN-regulatory genes, suggesting this module may represent a JAK-STAT regulatory layer adjacent to the IFN response.
Genes
Most correlated modules
- Innate Myeloid Sensing · correlation 0.81
- IFN-gamma Response · correlation 0.75
- Type I Interferon · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.