IFN-gamma Response
Gene co-expression module in Dendritic cells
| Category | Pathogen response |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 20 genes have a known function matching the annotation |
Why this annotation
The module is dominated by GBP1, GBP2, GBP4, GBP5 (guanylate-binding proteins, hallmark IFN-γ-induced GTPases), STAT1 (master IFN transcription factor), CXCL9, CXCL10 (IFN-γ-induced chemokines), ISG20, IFITM3, IFIH1 (MDA5, cytosolic RNA sensor), PARP9, PARP14, SAMD9L, ANKRD22 — all well-established interferon-stimulated genes (ISGs). TAP1 links to antigen presentation. The very high delta_inflammation scores (especially CD: 1.21) confirm strong induction in IBD inflammation. This is a canonical IFN-γ / type II interferon response module in mDCs, distinct from the type I IFN module (M1) which features MX1, ISG15, IFIT2, STAT2, IRF7.
Genes
Most correlated modules
- ER Proteostasis Stress · correlation 0.87
- Tolerogenic mDC Activation · correlation 0.79
- Type I Interferon · correlation 0.76
- JAK-STAT Cytokine Signaling · correlation 0.75
- Proliferating DC Mixed · correlation 0.71
- Innate Myeloid Sensing · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.