DNA Replication Support
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
ASF1A (histone chaperone essential for DNA replication), TOPBP1 (DNA replication initiation/checkpoint, enriched in prolif_DC), and LRR1 (replication licensing, enriched in prolif_DC 4x) anchor a DNA replication theme. AKT1 and PRKCA provide survival/proliferation signaling. PCYT1A (phosphatidylcholine synthesis) and COA4 (mitochondrial assembly) suggest metabolic support for proliferating cells. ADA (adenosine deaminase, purine recycling) fits proliferative nucleotide demand. Moderate coherence with mixed membership reflects combination of replication and metabolic support programs in proliferating DCs.
Genes
Most correlated modules
- Telomere Maintenance · correlation 0.89
- Endosomal Vesicle Trafficking · correlation 0.86
- hnRNP Splicing Program · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.