Telomere Maintenance
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence and low expression. Hub genes: HMGXB4 (chromatin remodeling, HMG box), CA2 (carbonic anhydrase 2, pH regulation), TERF1 (telomere repeat binding factor, telomere maintenance), MTAP (methylthioadenosine phosphorylase, methionine salvage), TMEM147 (ER membrane), MRPL1 (mitochondrial ribosomal protein), ESF1 (rRNA processing), PANK2 (coenzyme A biosynthesis), CASP8AP2 (FLASH, apoptosis/histone gene regulation), CTPS1 (CTP synthase, nucleotide synthesis), TERF1 (telomere). Several genes point to DNA/chromatin maintenance and telomere biology (TERF1, HMGXB4, CASP8AP2). CTPS1 and MTAP suggest nucleotide metabolism. Some prolif_DC enrichment. GEM (GTPase) and ARHGAP30 (Rho GAP) add cytoskeletal flavor. The module is mixed but telomere/chromatin maintenance with nucleotide metabolism is the best fit given hub gene identity. Moderate coherence is consistent with a mixed program.
Genes
Most correlated modules
- Vesicular Housekeeping · correlation 0.91
- Ribosome Biogenesis · correlation 0.90
- DNA Replication Support · correlation 0.89
- Endosomal Vesicle Trafficking · correlation 0.88
- ER Protein Biogenesis · correlation 0.88
- hnRNP Splicing Program · correlation 0.87
- DC Proliferation Program · correlation 0.86
- RNA Processing Proliferation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.