Endosomal Vesicle Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes SNX5 (sorting nexin-5, endosomal retromer trafficking), TBC1D10C (Rab GTPase-activating protein), AP1B1 (AP-1 clathrin adaptor beta1 subunit), EPN1 (epsin-1, clathrin-mediated endocytosis), NEU1 (lysosomal sialidase), BIN2 (amphiphysin-like, membrane curvature/endocytosis), GRK6 (GPCR kinase regulating receptor internalization), and IFT57 (intraflagellar transport/vesicle trafficking) collectively define an endosomal/vesicular trafficking program. APEH (acylpeptide hydrolase) and SLC1A5 (amino acid transporter) are peripheral. This module is consistent with endocytic recycling and membrane trafficking in DCs. Neighbor context: adjacent to M37 (ER biogenesis) and M20 (RNA processing), suggesting a coordinated biosynthetic-to-trafficking axis in cDC1/prolif_DC.
Genes
Most correlated modules
- Vesicular Housekeeping · correlation 0.93
- Ribosome Biogenesis · correlation 0.91
- DC Proliferation Program · correlation 0.89
- Telomere Maintenance · correlation 0.88
- ER Protein Biogenesis · correlation 0.87
- DNA Replication Support · correlation 0.86
- RNA Processing Proliferation · correlation 0.85
- cDC1 Epigenetic Regulation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.