TMC5/ACSL5 epithelial axis
Gene co-expression module in Enteroendocrine cells
| Category | Metabolic regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
No subset reaches 3x; the genes skew mildly toward EC and K cells, which are abundant in the proximal small intestine. Hub genes are shared intestinal-epithelial genes (TMC5, ATP2C2) plus small-intestine metabolic genes (ACSL5, HGD), consistent with a regional epithelial axis rather than contamination. The only link is a modest correlation with EC Membrane Signaling, so the program remains poorly defined.
Genes
Most correlated modules
- Synaptic scaffold/regulators · correlation 0.65
- CASR/GIRK membrane sensing · correlation 0.50
- TRPA1/ADH4 chemosensory EC · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.