Synaptic scaffold/regulators
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
All genes are enriched only in EC cells, led by GRIP2, OPCML, DACH2 and HDAC9 (HDAC9 in 83% of EC cells). Together they form a coherent program of synaptic scaffold, adhesion and transcriptional regulators that marks an EC subtype or maturation state rather than serotonin biosynthesis.
Genes
Most correlated modules
- TF-defined EC subtype · correlation 0.90
- SYT1/ATP6V1C2 vesicle genes · correlation 0.87
- EC accessory genes · correlation 0.86
- CDH22/SPATA17 EC markers · correlation 0.85
- FHL1/SCN8A EC state · correlation 0.83
- GREM2/CDH26 EC subset · correlation 0.83
- GULP1/PRDM16 EC genes · correlation 0.82
- EC Calcium-Triggered Exocytosis · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.