CASR/GIRK membrane sensing
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes peak in EC cells, with D and K cells close behind. They include the Ca2+-sensing receptor CASR, the GIRK channel KCNJ3, the GABA-A subunit GABRB1, the CGRP co-receptor RAMP1 and PIP5K1B, together pointing to a membrane sensing program. Its strong correlation (0.84) with the CALCR/CDHR3 EC identity module supports EC attribution, though enrichment is modest and several hubs are spread.
Genes
Most correlated modules
- CALCR/CDHR3 EC program · correlation 0.79
- EC Neuronal Excitability · correlation 0.71
- LMX1A/VMAT1 EC identity · correlation 0.62
- Peptidergic Secretory Granule · correlation 0.56
- TMC5/ACSL5 epithelial axis · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.