TRPA1/ADH4 chemosensory EC
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The hubs are concentrated in a fraction of EC cells: NDST3 (27.5x), ADH4 (25.8x), KCNE4 (33.5x), UGT2B7 (10x) and FRAS1 (9x). Together with TRPA1, the electrophile/irritant sensor of EC cells, they mark a chemosensory, xenobiotic-handling EC subpopulation. Its strong correlation with the SCN3A/HCN1 EC excitability module supports EC identity, and EC localization argues against goblet or colonocyte contamination.
Genes
Most correlated modules
- LMX1A/VMAT1 EC identity · correlation 0.69
- SCN3A/HCN1 EC excitability · correlation 0.65
- RASGRP1/MME K-cell signaling · correlation 0.59
- CES1/TRPC7 EC subset · correlation 0.58
- Serotonergic EC specification · correlation 0.52
- EC Neuronal Excitability · correlation 0.47
- TMC5/ACSL5 epithelial axis · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.