Ghrelin/Motilin M/X-cell
Gene co-expression module in Enteroendocrine cells
| Category | Hunger regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
The hubs GHRL (128x) and MLN (79x) are the defining hormones of small-intestinal M/X cells. With the vesicle genes SV2B and NSG2 and the Ca2+ channel CACNA1E, all localized to MX cells, they form the M/X-cell orexigenic and motility hormone program.
Genes
Most correlated modules
- Proximal MX/I-cell signature · correlation 0.67
- LGR5/NUMBL immature state · correlation 0.45
- ARX+ Peptidergic Lineage · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.