Proximal MX/I-cell signature
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 7 genes have a known function matching the annotation |
Why this annotation
The hubs ONECUT2, TM4SF4, DPEP1, SERPINA1 and AZGP1 are proximal small-intestinal epithelial positional genes. They are enriched at least 3x in MX and I cells, and the module correlates strongly with the Ghrelin/Motilin M/X-cell program, so it is a regional program of proximal EEC subsets rather than contamination. PGM5 is an MX-restricted outlier, and CD74 overlap with the myeloid neighbour is limited because its expression is subset-localized.
Genes
Most correlated modules
- CDX2/HNF4G intestinal identity · correlation 0.76
- Small-intestinal absorptive signature · correlation 0.72
- Small-intestinal nutrient metabolism · correlation 0.71
- Peptide tyrosine sulfation · correlation 0.71
- Rho-GEF cytoskeletal signaling · correlation 0.70
- Proximal regional identity · correlation 0.69
- Peptidergic neuronal-type genes · correlation 0.69
- Ghrelin/Motilin M/X-cell · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.