ARX+ Peptidergic Lineage
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
The lineage transcription factors ARX, PAX6 and PAX3 define the module, together with the bile-acid receptor GPBAR1 and PRPH, all enriched across peptidergic L/K/I/N/MX subsets rather than EC cells. This marks the shared non-enterochromaffin hormone lineage, which fits its modest correlation with the I-cell identity signature. AIF1 and S100Z are minor myeloid-type members.
Genes
Most correlated modules
- Small-intestinal Nutrient Sensing · correlation 0.67
- Respiratory chain subunits · correlation 0.63
- GLP-1/PYY hormone program · correlation 0.49
- Crypt-positioned EEC state · correlation 0.48
- Biosynthetic housekeeping machinery · correlation 0.47
- Abundant housekeeping transcripts · correlation 0.45
- I-cell identity signature · correlation 0.40
- Ghrelin/Motilin M/X-cell · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.