RNA Processing Translation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
EIF3A and EIF1AX are translation initiation factors; HNRNPC and HNRNPK are major heterogeneous nuclear RNA-binding proteins involved in pre-mRNA processing; PRPF40A is a pre-mRNA splicing factor; GSPT1 is a translation termination factor (eRF3); NIFK is a ribosome biogenesis factor (Ki-67 interactor); THRAP3 (TRAP150) is an RNA-binding transcription coactivator; SSB (La antigen) stabilizes nascent RNA Pol III transcripts; MTDH (metadherin/AEG-1) is an RNA-binding oncogene; HOOK1 is a cytoskeletal/dynein adaptor (peripheral). The module is dominated by RNA processing and translation machinery. Moderate/weak membership of several genes reflects the broad housekeeping nature. Neighbor M23 also has RNA processing genes, and M66 overlaps in RNA-binding proteins.
Genes
Most correlated modules
- Housekeeping Transcription · correlation 0.96
- ER Targeting & Trafficking · correlation 0.92
- TRiC Chaperonin Complex · correlation 0.92
- Intestinal Progenitor Identity · correlation 0.91
- ER Membrane Organization · correlation 0.88
- Chromatin RNA Processing · correlation 0.88
- ER Protein Translocation · correlation 0.88
- Nuclear Housekeeping · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.