Housekeeping Transcription
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
TFAM drives mitochondrial transcription; HSPA9 is a mitochondrial chaperone; YY1 is a general transcription factor; HNRNPM, PTBP3, SYNCRIP are RNA-binding proteins; TCEA1 is a transcription elongation factor; IPO7 is an importin for nuclear import; EIF2S2 is a translation initiation factor subunit; CCT3 is a chaperonin subunit; TBL1XR1 is part of the NCoR/SMRT repressor complex; OLA1 is a GTPase involved in translation regulation; PPIG is a cyclophilin involved in splicing. The module is a mixed housekeeping program spanning RNA processing, transcription regulation, and mitochondrial function. Moderate/weak membership of several genes confirms mixed nature. Restored in remission suggests these are normal progenitor housekeeping programs suppressed during inflammation.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.96
- TRiC Chaperonin Complex · correlation 0.94
- ER Targeting & Trafficking · correlation 0.93
- Chromatin RNA Processing · correlation 0.92
- ER Protein Folding · correlation 0.92
- DNA Damage Repair · correlation 0.90
- Intestinal Progenitor Identity · correlation 0.88
- Epithelial Cell Adhesion · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.