ER Membrane Organization
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
RTN4 (reticulon-4, ER membrane shaping and ER-Golgi transport), RAB1A (ER-to-Golgi vesicular transport), RAB11A (recycling endosome trafficking), VAPA (VAMP-associated protein A, ER membrane contact sites and lipid transfer), PTP4A2 (PRL-2 phosphatase, membrane-associated signaling), MYL12A/MYL12B (non-muscle myosin IIA regulatory light chains), PRELID3B (mitochondrial intermembrane space lipid transfer). The dominant theme is ER membrane organization and vesicular/endosomal trafficking, with RTN4, RAB1A, RAB11A, and VAPA as clear ER/trafficking genes. MYL12A/B may reflect actomyosin involvement in vesicle budding. This module is a topological neighbor of M87 (ER translocation) and M42 (ER targeting), forming a coherent ER/membrane trafficking neighborhood.
Genes
Most correlated modules
- ER Protein Trafficking · correlation 0.93
- ER Protein Folding · correlation 0.93
- ER Protein Translocation · correlation 0.92
- ER Protein Processing · correlation 0.92
- Oxidative Phosphorylation · correlation 0.91
- ER Targeting & Trafficking · correlation 0.90
- Intestinal Progenitor Identity · correlation 0.89
- RNA Processing Translation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.